Article
A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jul 2007
Gosling Katharine M, Makaroff Lydia E, Theodoratos Angelo, Kim Yong-Hee, Whittle Belinda, Rui Lixin, Wu Hua, Hong Nancy A, Kennedy Gavin C, Fritz Julie-Anne, Yates Adele L, Goodnow Christopher C, Fahrer Aude M
Abstract excerpt
Condensins are ubiquitously expressed multiprotein complexes that are important for chromosome condensation and epigenetic regulation of gene transcription, but whose specific roles in vertebrates are poorly understood. We describe a mouse strain, nessy, isolated during an ethylnitrosourea screen for recessive immunological mutations. The nessy mouse has a defect in T lymphocyte development that decreases...
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