Article

The condensin II/TOP-2 axis silences transcription during germline specification in <i>C. elegans</i>

2022-08-31

Abstract excerpt

In C. elegans , the germline is specified via a preformation mechanism that relies on the PIE-1 protein’s ability to globally silence mRNA transcription in germline precursor cells, also known as the P-lineage. Recent work from our group has identified additional genome silencing events in C. elegans during oogenesis and in starved L1 larvae, and these require the condensin II complex, topoisomerase II (TOP-2),...

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Literature Corpus work: ffd9b2e0-705c-5ffc-9162-0c56f6c2d693
DOI: 10.1101/2022.08.30.505898

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