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Article

Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain.

Genetics - 6 Dec 2023

Mannino Maria C, Cassidy Mercedes Bartels, Florez Steven, Rusan Zeid, Chakraborty Shalini, Schoborg Todd

Abstract excerpt

The coordination of cellular behaviors during neurodevelopment is critical for determining the form, function, and size of the central nervous system (CNS). Mutations in the vertebrate Abnormal Spindle-Like, Microcephaly Associated (ASPM) gene and its Drosophila melanogaster ortholog abnormal spindle (asp) lead to microcephaly (MCPH), a reduction in overall brain size whose etiology remains poorly defined. Here,...

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Identifiers

PMID: 37831641
DOI: 10.1093/genetics/iyad188
PMCID: PMC10697820

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