Article

N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in <i>Drosophila</i>

2025-03-13

Abstract excerpt

Histone deacetylase four (HDAC4) undergoes dynamic nucleocytoplasmic shuttling, which is important in the regulation of its activity. However, aberrant nuclear accumulation of HDAC4 is associated with both neurodevelopmental and neurodegenerative disease, and in our Drosophila model, impairs normal neuronal development. Upon nuclear accumulation, HDAC4 forms biomolecular condensates, previously termed aggregates,...

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Literature Corpus work: d3595b2a-1beb-55b0-8e66-bfbb55be605b
DOI: 10.1101/2025.03.10.642474

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