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Article

Epilepsy and premature mortality driven by inhibitory neuron dysfunction in a mouse model of <i>SCN1A</i> gain-of-function neurodevelopmental disorder

2026-08-09

Abstract excerpt

<h4>ABSTRACT</h4> The gene most commonly implicated in epilepsy, SCN1A , encodes the neuronal voltage-gated sodium channel subunit NaV1.1. SCN1A variants that reduce sodium current (“loss of function” variants) cause Dravet syndrome, a neurodevelopmental disorder defined by treatment-resistant temperature-sensitive epilepsy with onset at/around 5 months of age, developmental delay/intellectual disability, and f...

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Literature Corpus work
66f03a25-02bd-5bee-9c21-3b74dcf9de51
DOI
10.64898/2026.08.04.742893
Open publication

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