Article

Altered auditory maturation in Fragile X syndrome and its involvement in audiogenic seizure susceptibility

2025-04-23

Abstract excerpt

<h4>Background</h4> Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability. In the brainstem, FMRP is necessary for normal development of acoustic reacti...

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Literature Corpus work: 662fd19e-4b0a-5304-bbc6-41895230fb0d
DOI: 10.1101/2025.04.22.650065

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