Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Apr 2025

Lerner Benjamin A, Gupta Samir, Burke Carol A, Kupfer Sonia, Katona Bryson W, Grady William M, Samadder Jewel J, Yurgelun Matthew B, Kelly Kaitlyn J, Moreno Prats Mariana, Joseph Nora, Idos Gregory E, Swanson Benjamin J, Kieber-Emmons AnnMarie, Weiss Jennifer M, Llor Xavier

Abstract excerpt

Gastric cancer is a significant global health concern, with CDH1-associated gastric cancer representing a small but important subset of cases. Historically, individuals with CDH1 pathogenic germline variants were advised to undergo prophylactic total gastrectomy due to the high reported risk of gastric cancer and the limited sensitivity of upper endoscopy in detecting signet ring cell carcinoma (SRCC). However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Cadherins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Signet Ring Cell

Share to Gastrectomy

Share to CDH1 gene

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Stomach Neoplasms

Source

Identifiers

PMID: 40203872
DOI: 10.6004/jnccn.2025.7006

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer.PMID 40203872Read ↗

Points to consider regarding prophylactic total gastrectomy in germline CDH1 variant carriers.Semantic proximity Read ↗

Adolescents and young adults with germline CDH1 variants and the risk of overtreatmentSemantic proximity Read ↗

Endoscopic Screening for Identification of Signet Ring Cell Gastric Cancer Foci in Carriers of Germline Pathogenic Variants in CDH1Semantic proximity Read ↗

Hereditary Diffuse Gastric Cancer Syndrome and the Role of CDH1: A Review.Semantic proximity Read ↗

Gastroscopic surveillance with targeted biopsies compared with random biopsies in CDH1 mutation carriersSemantic proximity Read ↗

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.Semantic proximity Read ↗

Total Gastrectomy for CDH-1 Mutation Carriers: An Institutional Experience.Semantic proximity Read ↗

Unique challenges of risk-reducing surgery for hereditary diffuse gastric cancer syndrome: a narrative review.Semantic proximity Read ↗

Overview on new progress of hereditary diffuse gastric cancer with CDH1 variants.Semantic proximity Read ↗

Surveillance and Surgical Considerations in Hereditary Diffuse Gastric Cancer.Semantic proximity Read ↗

Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation statusSemantic proximity Read ↗

Hereditary diffuse gastric cancer: What the clinician should knowSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.