Article

Impact of cell culture on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells

2022-02-09

Abstract excerpt

<h4>Summary</h4> The alveolar epithelial type 2 cell (AEC2) is the facultative progenitor of lung alveoli tasked to maintain distal lung homeostasis. AEC2 dysfunction has been implicated in the pathogenesis of a number of pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), highlighting the importance of human in vitro models of the alveolar epithelium. However, AEC2-like cells captured in cell cul...

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Literature Corpus work: fae5e991-80cd-5e82-b11e-27fab752cdbb
DOI: 10.1101/2022.02.08.479591

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