Article
Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study.
EBioMedicine - 1 Sept 2026
Guan Jun, Zhu Jingtan, Li Yuting, Nie Min, Zhang Jing, Chen Zhiheng, Liu Huadie, Chen Dan-Na, Zheng Ruizhi, Men Meichao, Li Jia-Da
Abstract excerpt
BACKGROUND: Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain genetically undefined. METHODS: Leveraging our 15-year effort in building one of Asia's largest CHH cohorts (812 unrelated patients, and...
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- Animals
- Humans
- Gonadotropin-Releasing Hormone
- Mice
- Neurogenesis
- Disease Models, Animal