Article

Reactivation of the progenitor gene Trim71 enhances the mitotic and hair cell-forming potential of cochlear supporting cells

2023-01-13

Abstract excerpt

Cochlear hair cell loss is a leading cause of deafness in humans. Neighboring supporting cells have some capacity to regenerate hair cells. However, their regenerative potential sharply declines as supporting cells undergo maturation (postnatal day 5 in mice). We recently reported that reactivation of the RNA-binding protein LIN28B restores the hair cell-regenerative potential of P5 cochlear supporting cells. Here...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 712675f1-b6bb-5d77-b125-c306345bc8ae
DOI: 10.1101/2023.01.12.523802

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reactivation of the progenitor gene Trim71 enhances the mitotic and hair cell-forming potential of cochlear supporting cellsDOI 10.1101/2023.01.12.523802Read

The RNA-binding protein TRIM71 is essential for hearing in humans and mice and regulates the timing of auditory sensory organ developmentSemantic proximity Read

Characterizing Adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochleaSemantic proximity Read

Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.Semantic proximity Read

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regenerationSemantic proximity Read

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner earsSemantic proximity Read

Single-cell atlas comparison across vertebrates reveals evolution of auditory cell types and mechanisms for hair cell regenerationSemantic proximity Read

LIN28B controls the regenerative capacity of neonatal murine auditory supporting cells through activation of mTOR signalingSemantic proximity Read

Development of the Mouse and Human Cochlea at Single Cell ResolutionSemantic proximity Read

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular OrgansSemantic proximity Read

Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.Semantic proximity Read

DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epitheliumSemantic proximity Read

Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cellsSemantic proximity Read