Article

Selectivity filter mutation in Na <sub>V</sub> 1.5 promotes ventricular tachycardia

2025-05-24

Abstract excerpt

Loss-of-Function (LoF) mutations in the SCN5A gene, which encodes for the predominant cardiac Na V isoform, Na V 1.5 result in either deficiency in the channel expression or function. Impaired Na V 1.5 expression and function underlie reduced peak Na + current (I Na ) and result in ventricular conduction velocity slowing, predisposing the heart to conduction block and ventricular arrhythmias clinically assoc...

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Literature Corpus work: a9ea6269-9d0c-5082-aea2-9437c962a8e6
DOI: 10.1101/2025.05.19.654350

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