Article
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002
Papadatos G Alex, Wallerstein Polly M R, Head Catherine E G, Ratcliff Rosemary, Brady Peter A, Benndorf Klaus, Saumarez Richard C, Trezise Ann E O, Huang Christopher L-H, Vandenberg Jamie I, Colledge William H, Grace Andrew A
Abstract excerpt
Voltage-gated sodium channels drive the initial depolarization phase of the cardiac action potential and therefore critically determine conduction of excitation through the heart. In patients, deletions or loss-of-function mutations of the cardiac sodium channel gene, SCN5A, have been associated with a wide range of arrhythmias including bradycardia (heart rate slowing), atrioventricular conduction delay, and...
Topics
- Animals
- Cell Survival
- Electrocardiography
- Electrophysiology
- Exons
- Heterozygote
- Homozygote
- Mice
- Models, Genetic
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Patch-Clamp Techniques