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Cas12a Ultra enables efficient genome editing in human multipotent and pluripotent stem cells

2023-10-24

Abstract excerpt

<title>Abstract</title><p>Background The development of the CRISPR-Cas12a platform has generated considerable interest in the genome editing community. Due to its AT-rich protospacer-adjacent motif (PAM, 5’-TTTV), Cas12a increased the potential number of targetable sites for gene editing beyond that of the prototypical<italic>Streptococcus pyogenes</italic>CRISPR-Cas9 system. Moreover, evaluation of the off-target...

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Literature Corpus work
a9e57eed-2955-5408-adc7-40aa56d39b41
DOI
10.21203/rs.3.rs-3403204/v1
Open publication

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Cas12a Ultra enables efficient genome editing in human multipotent and pluripotent stem cellsDOI 10.21203/rs.3.rs-3403204/v1
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