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Current advances of CRISPR-Cas technology in cell therapy

26 Oct 2022

Abstract excerpt

CRISPR-Cas is a versatile genome editing technology that has been broadly applied in both basic research and translation medicine. Ever since its discovery, the bacterial derived endonucleases have been engineered to a collection of robust genome-editing tools for introducing frameshift mutations or base conversions at site-specific loci. Since the initiation of first-in-human trial in 2016, CRISPR-Cas has been...

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PMID: 37193354
DOI: 10.1016/j.cellin.2022.100067

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