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The changing landscape of gene editing in hematopoietic stem cells: a step towards Cas9 clinical translation

14 Aug 2017

Abstract excerpt

PURPOSE OF REVIEW: Since the discovery two decades ago that programmable endonucleases can be engineered to modify human cells at single nucleotide resolution, the concept of genome editing was born. Now these technologies are being applied to therapeutically relevant cell types, including hematopoietic stem cells (HSC), which possess the power to repopulate an entire blood and immune system. The purpose of this...

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PMID: 28806273
DOI: 10.1097/moh.0000000000000385

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