Article

DRB1 Subtyping Reveals Divergent Risk and Protection for Type 1 Diabetes in Middle Eastern Populations

2025-12-02

Abstract excerpt

<h4>Background</h4> Type 1 diabetes (T1D) is strongly influenced by HLA variation, yet current genetic risk models developed largely in European cohorts perform suboptimally in Middle Eastern populations due to region-specific allele frequencies, DR4 subtype heterogeneity, and distinct haplotype structures. We aimed to characterize HLA diversity in the Qatar Biobank (QBB) cohort and develop a Middle East optimize...

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Literature Corpus work: a9e376d6-2a5e-5d1b-846a-f0a4b573d595
DOI: 10.64898/2025.12.01.25341336

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