Article

Genetic association of T1D stratified by HLA DR3 and DR4 status reveals heterogeneity in pathways of progression to T1D

2025-08-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> There are substantial differences in the clinical presentation of type 1 diabetes (T1D) depending on the first-developing autoantibody, although the underlying mechanisms are poorly understood. The DR3-DQ2 (DR3) and DR4-DQ8 (DR4) haplotypes at the MHC locus closely associate with GAD and IAA as the first-developing autoantibody, respectively, and can therefore be used as pro...

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Literature Corpus work: cf5627fa-5664-583f-8d6f-eee4ef9e3786
DOI: 10.1101/2025.08.13.25333386

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