Genetic association and machine learning improve the prediction of type 1 diabetes risk.

Abstract excerpt

Type 1 diabetes (T1D) has a large genetic component, and expanded genetic studies of T1D can enhance biological and therapeutic discovery and improve risk prediction. Here we performed genome-wide genetic association and fine-mapping analyses in 20,355 T1D and 797,363 nondiabetic individuals of European ancestry and in 10,107 T1D and 19,639 nondiabetic individuals at the MHC locus, which identified 160 risk...

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