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Y665F variant of mouse <i>Stat5b</i> protects against acute kidney injury through transcriptomic shifts in renal gene expression

2025-02-23

Abstract excerpt

<h4>ABSTRACT</h4> The impact of single nucleotide polymorphisms (SNP) on physiology is often underestimated. One amino acid change can result in a variety of phenotypes apparent only in response to disease or injury. Even known pathogenic SNPs have widespread effects that are currently unaccounted for. In this study, we investigated the impact of the known activating and pathogenic STAT5B Y665F mutation in a re...

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Literature Corpus work
a9df2182-6aff-5e6e-8063-e71abaa47495
DOI
10.1101/2025.02.19.639141
Open publication

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Y665F variant of mouse <i>Stat5b</i> protects against acute kidney injury through transcriptomic shifts in renal gene expressionDOI 10.1101/2025.02.19.639141
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