Article

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney disease

2022-10-11

Abstract excerpt

The glomerulus mediates kidney ultrafiltration through specialised epithelial cells called podocytes which line a basement membrane shared with blood capillary endothelium. Cell-cell crosstalk is critical for glomerular function, but its investigation in childhood glomerular diseases has received little attention. WT1 encodes a transcription factor expressed in podocytes, whose heterozygous variants cause devasta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4dd45888-615f-5a40-8a3b-5c8dcf60f67b
DOI: 10.1101/2022.10.11.511555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney diseaseDOI 10.1101/2022.10.11.511555Read

Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease.Semantic proximity Read

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read

A Single-Cell Transcriptome Atlas of the Mouse GlomerulusSemantic proximity Read

Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to InjurySemantic proximity Read

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney developmentSemantic proximity Read

Integrated Single-Cell Transcriptomic Atlas of Human Kidney Endothelial CellsSemantic proximity Read

Towards an understanding of kidney diseases associated with WT1 mutations.Semantic proximity Read

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read

Clinical Aspects of WT1 and the Kidney.Semantic proximity Read

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomesSemantic proximity Read

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injurySemantic proximity Read