Article

Sexually dimorphic renal expression of <i>Klotho</i> is directed by a kidney-specific distal enhancer responsive to HNF1b

2024-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Transcription enhancers are genomic sequences regulating common and tissue-specific genes and their disruption can contribute to human disease development and progression. Klotho , a sexually dimorphic gene specifically expressed in kidney, is well-linked to kidney dysfunction and its deletion from the mouse genome leads to premature aging and death. However, the sexually dimorphic regulation o...

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Literature Corpus work: 07798abd-a674-5a1c-9270-bba5ed1961eb
DOI: 10.1101/2024.02.29.582831

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