Article

Irbesartan ameliorates kidney injury and anemia in a Col4a5-mutant mouse model of Alport syndrome with CKD pathology

2026-03-06

Abstract excerpt

<title>Abstract</title> <p> Alport syndrome, caused by mutations in type IV collagen genes, leads to progressive proteinuria, anemia, and glomerulosclerosis, ultimately resulting in renal failure. It also shares pathological features with chronic kidney disease (C KD). Previous knockout models of <italic>Col4a3</italic> or <italic>Col4a5</italic> recapitulated renal disease but were less translatable to the...

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Literature Corpus work: 4714d87a-5937-54e8-818b-6cb8b23820e3
DOI: 10.21203/rs.3.rs-8786563/v1

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