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Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

5 Apr 2018

Abstract excerpt

Our understanding of kidney disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ's multiple homeostatic functions. To help fill this knowledge gap, we characterized 57,979 cells from healthy mouse kidneys by using unbiased single-cell RNA sequencing. On the basis of gene expression patterns, we infer that inherited kidney diseases that arise from...

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PMID: 29622724
DOI: 10.1126/science.aar2131

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