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Article

Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75

11 May 2021

Abstract excerpt

Background and Purpose The G‐protein‐coupled receptor GPR75 (Gq) and its ligand, the cytochrome P450‐derived vasoactive eicosanoid 20‐hydroxyeicosatetraenoic acid (20‐HETE), are involved in the activation of pro‐inflammatory and hypertensive signalling cascades contributing to diabetes, obesity, vascular dysfunction/remodelling, hypertension and cardiovascular disease. Little is known as to how, where and with...

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PMID: 33974269
DOI: 10.1111/bph.15525

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