Article

Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation

2022-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal survival outcomes. A major barrier in the field has been the relative paucity of human tumors studied. Here we provide an integrated analysis of 3,600 “real-world” SCLC cases. This large cohort allowed us to identify new recurrent alterations and new genetic subtypes, including STK11- mutant tumors (1.7%) and...

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Literature Corpus work: 2ea3977f-aa2c-5cb8-a4c7-c2251bc58196
DOI: 10.1101/2022.07.27.501738

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