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A Digital Twin of Glimepiride for Personalized and Stratified Diabetes Treatment

2025-06-17

Abstract excerpt

Optimizing glimepiride therapy for type 2 diabetes (T2DM) is challenged by pronounced inter-individual variability in pharmacokinetics. To address this, we developed a whole-body physiologically based pharmacokinetic (PBPK) model as a digital twin of glimepiride. This model enables systematic evaluation of how patient-specific factors influence glimepiride disposition, supporting both personalized and stratified t...

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Literature Corpus work
a9c7fc31-afe1-5a8c-9ca4-c866d4b2424c
DOI
10.20944/preprints202506.1264.v1
Open publication

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A Digital Twin of Glimepiride for Personalized and Stratified Diabetes TreatmentDOI 10.20944/preprints202506.1264.v1
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