Article
Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
CPT: pharmacometrics & systems pharmacology - 1 Jul 2021
Fendt Rebekka, Hofmann Ute, Schneider Annika R P, Schaeffeler Elke, Burghaus Rolf, Yilmaz Ali, Blank Lars Mathias, Kerb Reinhold, Lippert Jörg, Schlender Jan-Frederik, Schwab Matthias, Kuepfer Lars
Abstract excerpt
Physiologically based pharmacokinetic (PBPK) models have been proposed as a tool for more accurate individual pharmacokinetic (PK) predictions and model-informed precision dosing, but their application in clinical practice is still rare. This study systematically assesses the benefit of using individual patient information to improve PK predictions. A PBPK model of caffeine was stepwise personalized by using...
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