Article

A Digital Twin of the Angiotensin II Receptor Blocker Losartan: Physiologically Based Modeling of Blood Pressure Regulation

2025-10-21

Abstract excerpt

Losartan, a commonly prescribed angiotensin II receptor blocker (ARB) used to treat hypertension and heart failure, shows significant variability in pharmacokinetics (PK) and pharmacodynamics (PD) among individuals. In this study, we developed a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model of losartan and its active metabolite, E3174, using curated data from 24 clinical trials. The model,...

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Literature Corpus work: aee59cd0-522f-5762-b76b-e7030ae7181c
DOI: 10.20944/preprints202510.1254.v1

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