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Article

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data.

Clinical pharmacology and therapeutics - 1 Sept 2026

Izat Nihan, Kangne Haribhau, Jansson-Löfmark Rasmus, Hertel Jens K, Rostami-Hodjegan Amin, Robertsen Ida, Galetin Aleksandra

Abstract excerpt

Plasma 4β-hydroxycholesterol (4β-OHC) normalized for the levels of its parent cholesterol (4β-OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β-OHC/C was measured pre-surgery (n = 54) and 2 years after Roux-en-Y gastric bypass (n = 30) and used as an input for creating virtual twins of each patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42317011
DOI: 10.1002/cpt.70369
PMCID: PMC13339604

Genes

CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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