Article

A PBPK Digital Twin of Rapamycin for Predicting Dose–Exposure Relationships, Organ Impairment Effects, and Drug–Drug Interactions

2026-05-06

Abstract excerpt

Sirolimus is a potent mTOR inhibitor used primarily to prevent acute rejection in transplant recipients. Its clinical management is challenging because of its narrow therapeutic index, low and highly variable oral bioavailability, and pronounced inter-individual variability driven by CYP3A4/5-mediated metabolism and P-glycoprotein efflux. Extensive partitioning into erythrocytes further complicates its disposition...

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Literature Corpus work: b4c15ad1-b900-515d-b9d2-23f91f0543f4
DOI: 10.20944/preprints202605.0328.v1

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