Article
Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.
Pharmacogenomics - 1 Apr 2016
Brian William, Tremaine Larry M, Arefayene Million, de Kanter Ruben, Evers Raymond, Guo Yingying, Kalabus James, Lin Wen, Loi Cho-Ming, Xiao Guangqing
Abstract excerpt
Genetic variants of drug metabolism enzymes and transporters can result in high pharmacokinetic and pharmacodynamic variability, unwanted characteristics of efficacious and safe drugs. Ideally, the contributions of these enzymes and transporters to drug disposition can be predicted from in vitro experiments and in silico modeling in discovery or early development, and then be utilized during clinical development....
Topics
- Drug Discovery
- Genetic Variation
- Humans
- Inactivation, Metabolic
- Membrane Transport Proteins
- Pharmacogenetics