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Digital Twin Metabolic Flux Profiling Enables Precise Prediction of Therapeutic Outcomes in Type 2 Diabetes

2025-12-04

Abstract excerpt

Treatment response in Type 2 Diabetes Mellitus (T2DM) is highly heterogeneous and difficult to predict using conventional clinical markers. Here, we apply digital-twin modeling of generalised metabolic fluxes (GMFs) to 60 T2DM patients treated with Dapagliflozin, Metformin, or their combination. GMF profiling revealed distinct post-treatment metabolic signatures, with Dapagliflozin exerting stronger effects on hep...

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Literature Corpus work
59b00ab9-16b1-574e-b3a7-a2b7fb66099b
DOI
10.64898/2025.12.04.25341430
Open publication

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Digital Twin Metabolic Flux Profiling Enables Precise Prediction of Therapeutic Outcomes in Type 2 DiabetesDOI 10.64898/2025.12.04.25341430
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