Article

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

2023-04-10

Abstract excerpt

<h4>SUMMARY</h4> SARS-CoV-2 continues to evolve and evade most existing neutralizing antibodies, including all clinically authorized antibodies. We have isolated and characterized two human monoclonal antibodies, 12-16 and 12-19, which exhibited neutralizing activities against all SARS-CoV-2 variants tested, including BQ.1.1 and XBB.1.5. They also blocked infection in hamsters challenged with Omicron BA.1 intrana...

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Literature Corpus work: 73dfd461-a8a2-58ed-a029-8e06ef9e23ab
DOI: 10.1101/2023.04.08.536123

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