Article

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

2020-12-01

Abstract excerpt

Antibodies are becoming a frontline therapy for SARS-CoV-2, but the risk of viral evolutionary escape remains unclear. Here we map how all mutations to SARS-CoV-2’s receptor-binding domain (RBD) affect binding by the antibodies in Regeneron’s REGN-COV2 cocktail and Eli Lilly’s LY-CoV016. These complete maps uncover a single amino-acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibo...

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Literature Corpus work: 65606807-8908-5603-8a02-6d21070f6089
DOI: 10.1101/2020.11.30.405472

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