Article

Proteolysis Targeting Chimeras With Reduced Off-targets

2021-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Proteolysis Targeting Chimeras (PROTACs), a class of heterobifunctional molecules that recruit target proteins to E3 ligases, have gained traction for targeted protein degradation. However, pomalidomide, a widely used E3 ligase recruiter in PROTACs, can independently degrade other targets, such as zinc-finger (ZF) proteins, that hold key functions in normal development and disease progression. T...

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Identifiers and source

Literature Corpus work: c492af4f-c619-59ea-817d-b4d12fb282b9
DOI: 10.1101/2021.11.18.468552

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