Article

Molecular and structural characterization of lenalidomide-mediated sequestration of eIF3i

2022-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Lenalidomide is a ligand of the E3 ligase substrate adaptor cereblon (CRBN) that achieves its clinical effects in part by promotion of substrate recruitment and degradation. In contrast to prior substrates, eIF3i is recruited but not degraded upon complex formation with lenalidomide and CRBN, although the structural details and mechanistic outcomes of this interaction are unresolved. Here, we ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b05ac4ac-2208-5948-9509-b67b5f09081e
DOI: 10.1101/2022.08.03.502648

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular and structural characterization of lenalidomide-mediated sequestration of eIF3iDOI 10.1101/2022.08.03.502648Read

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma CellsSemantic proximity Read

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myelomaSemantic proximity Read

Design of a Cereblon construct for crystallographic and biophysical studies of protein degradersSemantic proximity Read

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradationSemantic proximity Read

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradationSemantic proximity Read

Mapping the latent CRBN-molecular glue degrader interactomeSemantic proximity Read

Epigenetic dysregulation of eukaryotic initiation factor 3 subunit E (eIF3E) by lysine methyltransferase REIIBP confers a pro-inflammatory phenotype in t(4;14) myeloma.Semantic proximity Read

Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myelomaSemantic proximity Read

Integrated proteomic screening reveals design principles of CRBN molecular glue degradersSemantic proximity Read

Molecular surface mimicry enables CRBN to target G3BP2 for degradationSemantic proximity Read

A Cryptic Interfacial Pocket Uncovered in Full CRL4 <sup>CRBN</sup> –IKZF3 Ubiquitylation Complex Enhances IMiD EfficacySemantic proximity Read

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small moleculesSemantic proximity Read