Article

Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation

2021-01-19

Abstract excerpt

<h4>Abstract(250)</h4> Loss of basal forebrain cholinergic projections occurs in Alzheimer’s disease, frontotemporal dementia and in aging. Moreover, nicotinic stimulation is anti-inflammatory in macrophages and microglia but how loss of basal forebrain acetylcholine impacts on microglial phenotype is poorly understood. Here we hypothesized that endogenous ACh maintains homeostatic microglial phenotype and that n...

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Literature Corpus work: a9bcb4fc-9651-5147-9767-bb6147a1cbcd
DOI: 10.1101/2021.01.18.427123

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