Article
Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson's Disease.
Molecules (Basel, Switzerland) - 21 Jan 2020
Kelly Rachel, Joers Valerie, Tansey Malú G, McKernan Declan P, Dowd Eilís
Abstract excerpt
Parkinson's disease is a neurodegenerative disorder, the motor symptoms of which are associated classically with Lewy body formation and nigrostriatal degeneration. Neuroinflammation has been implicated in the progression of this disease, by which microglia become chronically activated in response to α-synuclein pathology and dying neurons, thereby acquiring dishomeostatic phenotypes that are cytotoxic and can...
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