Article

Noradrenergic signaling controls Alzheimer’s disease pathology via activation of microglial β2 adrenergic receptors

2023-12-04

Abstract excerpt

In Alzheimer’s disease (AD) pathophysiology, plaque and tangle accumulation trigger an inflammatory response that mounts positive feed-back loops between inflammation and protein aggregation, aggravating neurite damage and neuronal death. One of the earliest brain regions to undergo neurodegeneration is the locus coeruleus (LC), the predominant site of norepinephrine (NE) production in the central nervous system (...

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Literature Corpus work: 0759d3f4-e8fb-52d0-af91-a17954d5da9d
DOI: 10.1101/2023.12.01.569564

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