Article

Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors

2024-02-26

Abstract excerpt

<title>Abstract</title> <p>Norepinephrine (NE) is a potent anti-inflammatory agent in the brain. In Alzheimer’s disease (AD), the loss of NE signaling heightens neuroinflammation and exacerbates amyloid pathology. NE inhibits surveillance activity of microglia, the brain’s resident immune cells, via their β2 adrenergic receptors (β2ARs). Here, we investigate the role of microglial β2AR signaling in AD pathology i...

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Literature Corpus work: 976e0e56-4cc9-500a-b055-2615fe36781f
DOI: 10.21203/rs.3.rs-3976896/v1

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