Article

Genetic interplay between type II topoisomerase enzymes and chromosomal <i>ccdAB</i> toxin-antitoxin in <i>E. coli</i>

2021-09-25

Abstract excerpt

Fluoroquinolones are one of the most widely used class of antibiotics. They target two type II topoisomerase enzymes: gyrase and topoisomerase IV. Resistance to these drugs, which is largely caused by mutations in their target enzymes, is on the rise and becoming a serious public health risk. In this work, we analyze the sequences of 352 extraintestinal E. coli clinical isolates to gain insights into the selectiv...

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Literature Corpus work: 21b07443-3dcd-5739-a2d4-0b9fb881baf3
DOI: 10.1101/2021.09.24.461737

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