Article

Cleavage of the catalytic intermediate fine-tunes cGAS signalling

2025-03-06

Abstract excerpt

Excessive activation of cyclic GMP–AMP synthase (cGAS) drives inflammatory and autoimmune diseases, but complete inhibition of cGAS signaling can compromise host defence. Here we show that cGAS signaling can be tuned through a previously unrecognized regulatory checkpoint. Bacterial cGAS generates cGAMP through a two-step mechanism involving release and rebinding of a 2′–5′-linked linear dinucleotide intermediate....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2375746-9129-5c10-a8ca-eaecf7a2a64e
DOI: 10.1101/2025.03.04.641389

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cleavage of the catalytic intermediate fine-tunes cGAS signallingDOI 10.1101/2025.03.04.641389Read

cGAMP the travelling messengerSemantic proximity Read

cGLRs are a diverse family of pattern recognition receptors in animal innate immunitySemantic proximity Read

A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathwaySemantic proximity Read

Regulation of the cGAS-STING PathwaySemantic proximity Read

Regulation of cGAS‐Mediated Immune Responses and ImmunotherapySemantic proximity Read

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell deathSemantic proximity Read

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cellsSemantic proximity Read

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1Semantic proximity Read

Function and regulation of cGAS-STING signaling in infectious diseasesSemantic proximity Read

cGAS‐STING pathway: post‐translational modifications and functions in sterile inflammatory diseasesSemantic proximity Read

Cyclic oligoadenylate signalling mediates <i>Mycobacterium tuberculosis</i> CRISPR defenceSemantic proximity Read

cGAS goes viral: A conserved immune defense system from bacteria to humansSemantic proximity Read