Article

SLC19A1 is an importer of the immunotransmitter cGAMP

2019-02-03

Abstract excerpt

2’3’-cyclic-GMP-AMP (cGAMP) is a second messenger that activates the antiviral Stimulator of Interferon Genes (STING) pathway. We recently identified a novel role for cGAMP as a soluble, extracellular immunotransmitter that is produced and secreted by cancer cells. Secreted cGAMP is then sensed by host cells, eliciting an antitumoral immune response. Due to the antitumoral effects of cGAMP, other CDN-based STING a...

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Literature Corpus work: e327ffe4-6643-5583-b502-218bbb37926d
DOI: 10.1101/539247

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