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Article

The impact of oncogenic mutations of the viral Src kinase on the structure and stability of the SH3 domain.

Acta crystallographica. Section D, Structural biology - 1 Jun 2021

Salinas-Garcia M Carmen, Plaza-Garrido Marina, Camara-Artigas Ana

Abstract excerpt

Src kinase belongs to the family of Src-related nonreceptor tyrosine kinases. Because of its physiological role in cell growth and proliferation, its activity is strictly controlled by several mechanisms. Nevertheless, in viral Src kinase (v-Src) some of these mechanisms fail, and its uncontrolled activity is responsible for the occurrence of cancer. Here, the crystal structures of three SH3-domain mutants of...

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PMID: 34076598
DOI: 10.1107/S2059798321004344
PMCID: PMC8171063

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