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Article

Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain.

Molecular cancer research : MCR - 1 Jun 2021

Ruiz-Saenz Ana, Zahedi Farima, Peterson Elliott, Yoo Ashley, Dreyer Courtney A, Spassov Danislav S, Oses-Prieto Juan, Burlingame Alma, Moasser Mark M

Abstract excerpt

The Src family kinases (SFK) are homologs of retroviral oncogenes, earning them the label of proto-oncogenes. Their functions are influenced by positive and negative regulatory tyrosine phosphorylation events and inhibitory and activating intramolecular and extramolecular interactions. This regulation is disrupted in their viral oncogene counterparts. However, in contrast to most other proto-oncogenes, the...

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Identifiers

PMID: 33727342
DOI: 10.1158/1541-7786.MCR-20-0825
PMCID: PMC8178206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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