Article

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis

2023-03-12

Abstract excerpt

<h4>SUMMARY</h4> Group A Streptococcus (GAS) infections can cause neuropsychiatric sequelae in children due to post-infectious encephalitis. Multiple GAS infections induce migration of Th17 lymphocytes from the nose into the brain, which are critical for microglial activation, blood-brain barrier (BBB) and neural circuit impairment in a mouse disease model. How endothelial cells (ECs) and microglia respond to GA...

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Literature Corpus work: a9439bbc-ad76-5b99-9fe0-8bb03b51a48a
DOI: 10.1101/2023.03.10.532135

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