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Article

Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2013

Conrady Christopher D, Zheng Min, van Rooijen Nico, Drevets Douglas A, Royer Derek, Alleman Anthony, Carr Daniel J J

Abstract excerpt

HSV-1 is the leading cause of sporadic viral encephalitis, with mortality rates approaching 30% despite treatment with the antiviral drug of choice, acyclovir. Permanent neurologic deficits are common in patients that survive, but the mechanism leading to this pathology is poorly understood, impeding clinical advancements in treatment to reduce CNS morbidity. Using magnetic resonance imaging and type I IFN...

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Share to Cell Line, Tumor
Share to Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Type I

Share to Lateral Ventricles

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Source

Open in PubMed Open full text

Identifiers

PMID: 23382563
DOI: 10.4049/jimmunol.1203265
PMCID: PMC3594081

Genes

CXCL1
CXCL10
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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