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Article

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in post-streptococcal encephalitis

2026-02-07

Abstract excerpt

Group A Streptococcus (GAS) infections can lead to neuropsychiatric sequelae in children, yet the mechanisms driving post-infectious brain pathology remain poorly defined. In a mouse disease model, Th17 lymphocytes induce microglial activation, blood–brain barrier (BBB) dysfunction, and neural circuit impairment; however, the transcriptional programs underlying these effects, and the specific Th17-derived cytokin...

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Literature Corpus work
6c89e2d0-5382-517e-8a5a-bca5947a5550
DOI
10.64898/2026.02.04.703836
Open publication

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Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in post-streptococcal encephalitisDOI 10.64898/2026.02.04.703836
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