Article

Brain infiltrating T cells mediate microglial dysregulation and neuronal loss following SAH

2025-10-11

Abstract excerpt

The contribution of T cells to neuroinflammation after aneurysmal subarachnoid hemorrhage (SAH) remains poorly understood. Using a murine pre-chiasmatic injection model of SAH we demonstrate that T cell infiltration into the brain modulates microglial activation and promotes neuronal death. Targeted transcriptomic profiling revealed a sustained neuroimmune response at 7 days post injury (dpi) characterized by a ma...

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Identifiers and source

Literature Corpus work: c285db84-3568-56ce-9fd9-3d785419ea3a
DOI: 10.1101/2025.10.10.681332

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