Article

De novo design of small-molecule–induced conformational change

2026-08-04

Abstract excerpt

Many biological proteins function by changing shape upon small-molecule binding. Here, we present a general strategy for designing de novo proteins that undergo small-molecule-induced conformational change. Our approach converts a preorganized small-molecule binding protein into a ligand-responsive shape-changer by adding a mobile lid domain that closes behind the ligand upon binding. Using this strategy, we conve...

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Identifiers and source

Literature Corpus work: ad28c48c-d0bf-5361-b0bd-22a3fbd2bc80
DOI: 10.64898/2026.08.03.742366

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